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We summarize here the similarities and differences of these two incretin hormones in secretion and metabolism, their insulinotropic action on pancreatic cells, and their noninsulinotropic effects, and discuss their potential in treatment of type 2 diabetes

In obese individuals without diabetes (BMI 30), administration of semaglutide (2.4 mg/week) for 68 weeks resulted in a 17.3% reduction in body weight

The dual mechanism is not incremental

But unfortunately, BMI is still used in clinical settings, especially to prescribe GLP-1s

Specific Drug Availability Wegovy is now approved and available for weight management in the UK