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Gastrointestinal tract Delayed gastric emptying increases satiety, blunts postprandial spikes, and reduces overall energy intake

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Gastric mechanoreceptors are activated by gastric distension following acute nutrient intake, and gastric mechanoreceptor signalling plays an important role as a meal-to-meal satiety signal, activating the NTS which in turn modulates neural activity in both the ARC the VTA[107] (the homeostatic and hedonic control of energy balance)

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