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388 doi: (Published 26 February 2025) Cite this as: BMJ 2025;388:e080679 Linked Editorial GLP-1 receptor agonists and suicidality Samantha B Shapiro, doctoral student1 2, Hui Yin, statistician1, Oriana Hoi Yun Yu, endocrinologist and associate professor2 3 4, Soham Rej, psychiatrist and associate professor5 6, Samy Suissa, professor1 2 7, Laurent Azoulay, professor1 2 8 1 Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada 2 Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada 3 Division of Endocrinology, Jewish General Hospital, Montreal, QC, Canada 4 Division of Endocrinology & Metabolism, McGill University, Montreal, QC, Canada 5 Department of Psychiatry, Jewish General Hospital, Montreal, QC, Canada 6 Department of Psychiatry, McGill University, Montreal, QC, Canada 7 Department of Medicine, McGill University, Montreal, QC, Canada 8 Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada Correspondence: L Azoulay laurent mcgill.ca (or @profLAzoulay on X) Accepted 24 January 2025 Abstract Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

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To investigate further expression of GLP-1R in normal islets, the GLP-1R distribution was examined in cells (central islet area) and cells (islet-periphery for GLP-1R

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