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Suppression of glutamatergic synaptic transmission may be associated with the reduced excitability of GLP-1R activation (Ong et al., 2017)

When to Seek Medical Advice About Digestive Changes Whilst mild to moderate digestive symptoms are expected with GLP-1 therapy, certain situations warrant prompt medical attention

Several studies have implied that FXR activation relieves intestinal inflammatory state in IBD patients, as well as that colonic inflammation in patients with CD and in rodent models of colitis is linked to diminished expression of FXR mRNA (Vavassori et al., 2009)

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