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In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

allowing the primary purification product to go through a chemically bonded silica gel chromatographic column in order to carry out secondary separation, carrying out gradient elution with an A2 solution and B solution mixed solution, and collecting an elution component to obtain a semaglutide solution, wherein the above A1 solution is a carbonate solution