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In addition, SCFAs can also lower the pH of the gut environment, prevent calcium ions from compounding with phosphorus to increase calcium absorption, and inhibit RANKL signaling pathway-induced osteoclastogenesis by suppressing osteoclast gene expression ( 3.2 GM affects bone homeostasis through the immune system The GM is essential for the function and maturation of the immune system, which stimulates the immune system at the gut mucosal barrier through the release of metabolites and immune cells (including T cells and B cells), the release of pro- or anti-inflammatory mediators as well as cytokines, and the regulation of systemic bone metabolism via the blood circulation (Schluter et al., 2020)

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