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The molecule was developed by Frank Ng's group at Monash University and Metabolic Pharmaceuticals in Australia during the 1990s and 2000s as a potential anti-obesity drug intended to isolate the lipolytic region of hGH without activating the growth hormone receptor or raising IGF-1.nnIn published preclinical work, the fragment has been shown to stimulate lipolysis, suppress lipogenesis, and modulate the beta-3 adrenergic receptor pathway in adipose tissue rather than acting through the classical hGH receptor

The usual prevention dose is 75mg once daily for 10 days

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101,102 Furthermore, high-fat/low-carbohydrate diets have been found to have negative impacts on LDL-cholesterol levels and vascular health in some studies, even while having positive impacts on HDL-cholesterol and triglyceride levels