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The effect of 2.4 mg once-weekly injected semaglutide in patients with HFpEF, obesity and T2D is currently investigated in an ongoing trial STEP-HFpEF DM (Semaglutide Treatment Effect in People with obesity and HFpEF and type 2 diabetes) (64, 65)

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Satiety signals become more pronounced

One is glucose, which comes from carbohydrates and fuels our brains, nervous system, muscles, and other cells

Injured hepatocytes release Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs) activate immune responses and recruit Kupffer cells, HSCs, and other immune cells to promote inflammation and fibrosis through cytokine signaling