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Active GLP-1 Forms Generated by the Gut and Brain In the gut and brain, proglucagon is then further processed into various proglucagon peptides, including active GLP-1 8,9
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Post-prandial levels of portal blood glucose are elevated and insulin levels decreased in rats with knockdown of GLP-1R in vagal afferent neurons, suggesting that GLP-1 also regulates blood glucose via activation of vagal afferent GLP-1 receptors [518]
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