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1 However, doctors sometimes prescribe it off-label for weight management due to its appetite-suppressing effects

Neuronal and Intracellular Signaling Pathways Mediating GLP-1 Energy Balance and Glycemic Effects

Javed M, et al

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These all involve substitutions of other aminoacids for cysteine, and are thought to cause activation of the gene by aberrant disulphide bonding causing dimerization
