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You'll also need 6 months of documented diet and exercise efforts , and you may need to try another weight loss medication first (step therapy)

That extra pathway is one reason researchers are interested in retatrutide, but it is also a reason not to assume its risk profile is identical to tirzepatides

Vegetables and fruit still need to be included even when appetite is low
Phase 2 trial data (NEJM, 2023) showed a mean body weight reduction of approximately 24% at the highest dose (12 mg weekly) over 48 weeks in adults without type 2 diabetes

Among respondents, 17% are currently taking a GLP-1
