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(17) Likewise, there was a reduction in the production of RANKL, thereby decreasing osteoclast mediated bone resorption

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PMID: 37947489 | doi:10.1080/13543784.2023.2283020 Melson E et al

Specifically, TNF induces inhibition of insulin-activated tyrosine phosphorylation of the insulin receptor and serine phosphorylation of IRS-1, which leads to inactivation of insulin signalling

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