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Insulin resistance exacerbated pathological PD features which contributed to disease progression via increases in -synuclein accumulation in dopaminergic neurons, oxidative stress, and mitochondrial dysfunction

While long understood as a microvascular disease, the central role of neuroinflammation and immune dysregulation is now increasingly clear

Key Takeaway Yes, the study found an increased relative risk , but the absolute number of cases is tiny

GIP amplifies that effect while also improving how your body handles insulin and glucose

A meta-analysis reported a weight loss of 4.19 kg (4.16%), a decrease in body mass index of 1.55 kg/m 2 , and a decrease in waist circumference of 3.11 cm when liraglutide was used [12]