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Moreover, to evaluate the responsiveness of the GRS to changes in glucose levels, the system was exposed to glucose concentrations which increased from 100 to 400 mg dl 1 , or periodically switched between 100 and 400 mg dl 1 at 1 h intervals

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Basal insulin helps regulate blood glucose levels throughout the day, while on-demand or bolus insulin is used to manage the blood glucose rise that follows meals

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