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Microbiome changes take time
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However, GLP-1RA therapy also induces persistent hypophagia and altered nutrient delivery kinetics, leading to chronically reduced systemic substrate inflow
doi: 10.2147/CIA.S74042 7 WangXFLinXLiDYZhouRGreenbaumJChenYCet al
This raises questions as to whether obesity medications may need to be used long term
