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Glucagon-like peptide-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR), is broadly expressed on the surfaces of various cells, including the pancreas, intestine and brain [8]

Muscle wasting in the context of T2D and obesity represents not only a complication but also a driver of disease progression, contributing to diminished insulin sensitivity, reduced physical capacity and adverse outcomes [3]

Overall, after 68 weeks, 83% of adults taking Wegovy lost 5% or more of their weight compared to 31% of adults taking a placebo

[6] [7] Important safety considerations include contraindications for patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and warnings regarding pancreatitis, gallbladder disease, and diabetic retinopathy complications

Cardiovasc Res 117(2):423434