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Brain insulin resistance is an important pathogenetic feature of AD and is mediated primarily by impaired insulin signaling (Sdzikowska and Szablewski, 2021)

Woo YS, Lim HK, Wang SM, Bahk WM

They also appear able to enhance microvascular (!) blood flows in the muscle tissue, reduce muscle-produced inflammation, and enhance glucose and lipid metabolism in the muscles

Therefore, GLP-1 agonists/analogues represent a continuously evolving class of drugs that can modulate mechanisms aimed at achieving increasingly ambitious glycemic and body weight goals