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These medications work by increasing satiety, reducing appetite, slowing gastric emptying, and improving insulin signaling

The modulatory effects of combined therapy with GLP-1RAs and other drugs on tumor risk As GLP-1RAs continue to see expanding clinical application, it is imperative that clinicians give careful consideration to the potential adverse effects linked to combination therapies

Clinical studies suggest that visceral abdominal fat may gradually increase after treatment is discontinued if healthy lifestyle habits are not maintained

The newer dual-action agent tirzepatide (Mounjaro) targets both GLP-1 and GIP receptors and is licensed in the UK for type 2 diabetes management

Indeed, because obesity is associated with so many comorbidities, drugmakers are now doing studies showing that GLP-1 drugs also show positive impact on conditions like sleep apnea and heart, liver, and kidney diseases