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Serotonin syndrome risk Do not take sertraline if you are taking, or have taken in the last 14 days, an MAOI antidepressant (such as phenelzine or selegiline), as this can cause a dangerous and potentially fatal rise in serotonin levels

They are meant for short-term use only

For individuals using GLP-1 medications, these guidelines are not optional

[51] Substitutions are made at GLP positions 8 and 34 (semaglutide positions 2 and 28), where alanine and lysine are replaced by 2-aminoisobutyric acid and arginine, respectively