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Tirzepatide is an approved GLP-1R/GIP dual agonist developed by Eli Lilly, garnering significant attention alongside SEMA in the field of T2DM and weight loss

As possible severity mechanisms, corticosteroid resistance, cytokines, and fatty acids should be considered

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Moreover, recognizing metainflammation as a therapeutic target is crucial, as it opens up new avenues for treatment strategies, such as using GLP-1 receptor agonists, which have both anti-inflammatory and weight-reducing properties that directly address these underlying metabolic abnormalities