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Indeed, the SELECT trial demonstrated that semaglutide reduced major adverse cardiovascular events (MACE) by 20% despite the modest heart rate increase

Because phentermine is a stimulant, its side effects often include an increased heart rate, elevated blood pressure, dry mouth, nervousness, and insomnia

These findings were confirmed in high-fat, high-cholesterol (HFHC) dietfed mice with functional LDL receptor deficiency induced by viral expression of proprotein convertase subtilisin/kexin type 9adeno-associated virus (PCSK9-AAV), in which daily administration of semaglutide for 18 weeks reduced aortic plaque area (11)

These benefits may be attributed to improved glycemic control, weight loss, reduced inflammation, and direct effects on blood vessels and the heart

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