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Back Secher, A, Jelsing, J, Baquero, et al (2014) 'The arcuate nucleus mediates GLP- 1RA liraglutide- dependent weight loss', Journal Clinical Investigation , 124, 447388

FDA-labeled warnings include: Risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) Pancreatitis (report severe abdominal pain, with or without vomiting) Gallbladder disease (including gallstones and cholecystitis) Acute kidney injury secondary to dehydration from gastrointestinal symptoms Hypoglycemia when used with insulin or insulin secretagogues (dose adjustments may be needed) Diabetic retinopathy complications in patients with type 2 diabetes and pre-existing retinopathy Suicidal behavior and ideation (monitor for depression or suicidal thoughts) Intestinal obstruction/ileus (particularly with severe constipation) These medications are contraindicated during pregnancy and should be discontinued at least two months before a planned pregnancy

The Novo Nordisk patient assistance program (PAP) also offers free Ozempic and Rybelsus to eligible individuals

This is a stimulus to the muscle to grow, and this leads to greater muscle mass

The STEP 1 extension study showed that participants who stopped semaglutide regained approximately two-thirds of their lost weight within a year