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Lower testosterone further promotes fat storage, which further increases aromatase activity

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[12] The therapeutic application of melatonin extends beyond primary sleep disorders to include potential benefits in managing sleep disturbances associated with neurodevelopmental conditions, neurodegenerative diseases, and certain psychiatric disorders

GLP-1 signaling has been shown to inhibit activation of the NLRP3 inflammasome, a key driver of innate immune-mediated inflammation, and to enhance Treg activity, suggesting a broader role in restoring immune tolerance [26,27]
