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Many patients are on a combination of an SGLT2 inhibitor with a GLP-1 receptor agonist or tirzepatide (a dual agonist) and have incredible success without adverse reactions, but we are still figuring out the patient characteristics that would put them at higher risk of poor outcomes. Eli J

To summarize, GLP-1RAs affect the metabolism of adipose tissue in both ways, by directly modulating preadipocyte differentiation and by mediating lipid metabolism processes, resulting in a reduction of lipogenesis and stimulation of lipolysis

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Among those excluded from weight loss medication coverage are those who have TRICARE For Life or direct care only access

This makes it relevant not only to obesity but also to MASH/NASH and broader metabolic syndrome