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Metformin may cause serious side effects, including: Lactic acidosis

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Embodiment 3 [0067] Synthesis of Compound 1: [0068] Add 83mL TFA to 53mL DCM and mix well, and cool to 3-5 degrees Celsius, add it to 16.50g crude product of compound 6 under ice bath, then transfer to room temperature and stir for 1.5h, spin dry, add toluene to spin Steam (100mL*3) to obtain a brown oil

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