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Whats worth knowing regardless: the drugs that started as diabetes medications and became weight loss medications may turn out to have a third significant clinical domain in psychiatry and the fact that GLP-1 receptors exist throughout the brain has been reshaping how researchers think about appetite, reward, impulsivity, and mood as genuinely interconnected rather than parallel systems

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Although the study did not focus on behavioral endpoints, they observed that patients with a documented history of AUD had lower odds of AUD recurrence during GLP-1RA treatment compared to those on other antidiabetic medications

In clinical trials, Semaglutide demonstrated remarkable effectiveness, with participants experiencing a reduction in body weight ranging from 5% to an astounding 20% within the first year of treatment

Serum was aliquoted, flash frozen in liquid N 2 , and stored at -80 C