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Fat mass decreases substantially, with visceral fat (the dangerous fat surrounding internal organs) dropping proportionally more than subcutaneous fat

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One traditional approach involves two separate operations, the first to remove the disease and divert the intestinal contents to a colostomy bag on the skin, and the second, several months later, to hook the colon and rectum back together (see Figure 3)

Data extracted from the selected studies included: study design, sample size, participant demographics, diagnostic criteria, intervention details, comparator, duration of treatment, outcome measures, key efficacy and safety results, and limitations

WY and A-MX contributed to the conception, design, and revision of the manuscript