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A new Alzheimer's disease interventive strategy: GLP-1

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Recent work suggests the possibility that this source of GLP-1 is also be important in regulating nutrient-induced insulin secretion in a paracrine fashion

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The SURMOUNT-5 head-to-head trial confirmed tirzepatide outperforms semaglutide by approximately 6 percentage points on average weight loss

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40 Reasons for discrepancies in magnitudes of effect could be that trial participants were generally enrolled with a higher baseline HbA1c, higher level of dysregulation, and longer diabetes duration, which could cause higher absolute differences between baseline achieved HbA1c levels at the end of the trial

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Reduced inflammation and improved metabolic markers

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