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Data in table derived from ClinicalTrials.gov CVOT cardiovascular outcome trial, GLP - 1 RA glucagon-like peptide-1 receptor agonist, QW once weekly Conclusions In conclusion, this review shows that long-acting GLP-1 RAs induce a pronounced and prolonged increase in 24-h mean HR, while short-acting agents lead to a more transient increase that reverts to baseline levels within a few hours after injection