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2 The condition has an incidence of 0.9 per 100 thousand people, exhibits a striking 8:1 female preponderance, and is frequently associated with obesity

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Stefanou MI, Palaiodimou L, Theodorou A, Safouris A, Fischer U, Kelly PJ, et al

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Because dopamine is both a central catecholamine transmitter and an essential intermediate in endogenous morphine biosynthesis, these signaling systems may be understood not as isolated processes but as components of a common evolutionary architecture