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Description
The most frequently reported adverse effects of tirzepatide are predominantly gastrointestinal in nature, reflecting the medication's mechanism of action on GLP-1 receptors in the digestive system

Food and Drug Administration , 2022, Amisi, C

In taste cells, SEMA3 is expressed in newly generated bitter taste cells and crucial for mediating a labeled-line connection to appropriate afferent bitter neurons [54]

If you've tried to flag your history and felt dismissed, that's worth addressing directly in therapy
Lancet 2013;381:117124
