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Research conducted with T2DM patients demonstrated that exenatide led to a 23% improvement in flow-mediated dilation, which served as an indicator of better endothelial function [27]

GLP-1R reduces oxidative damage accumulation by modulating autophagy-related proteins and scavenging damaged mitochondria while increasing superoxide dismutase (SOD) and glutathione peroxidase activities, reducing the generation of lipid peroxidation products, inhibiting the NF-B signaling pathway, and decreasing proinflammatory factor expression to reduce neuroinflammation (Ma et al., 2018

Multidisciplinary care involving physicians, dietitians, diabetes educators, and mental health professionals optimizes outcomes and addresses the complex pathophysiology of metabolic disease

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for example, by reducing rates of cardiovascular disease or chronic kidney disease