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In this regard, GLP-1R agonists (i.e., exenatide) improve insulin resistance suppressing pro-inflammatory phenotypes of monocytes/macrophages, and directly modulating NF-B activation and IL-1, IL-6, and TNF- expression (Yu et al., 2019)
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Leptin treatment enhanced hepatic insulin sensitivity of the MKR mice by suppression of hepatic glucose production during the hyperinsulinemiceuglycemic clamp
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