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127-OR: The effect of tirzepatide during weight loss on metabolic adaption, fat oxidation, and food intake in people with obesity

At 5 mg, tirzepatide reaches its first therapeutic dose

Additionally, weight loss can be enhanced by engaging in a consistent exercise routine that includes cardio exercise and strength or resistance training

The Phase 2b IMPACT trial demonstrated MASH resolution without worsening fibrosis, with weight losses of 4-6% over 24 weeks at current doses

We will cover metabolic adaptation, dosing issues , dietary mistakes, muscle loss, hormonal interference, and the dozen other factors that determine whether tirzepatide delivers transformative results or frustrating stagnation