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Survodutide (BI 456906) is a GLP-1R/GCGR dual agonist developed by Boehringer Ingelheim, with outcomes of a phase 2 trial in MASLD and a phase 1 trial in cirrhosis published almost simultaneously with tirzepatide

A peptide hormone typically has extended binding interactions with the receptor exactly mimicking these interactions with a small molecule is impossible

Possible mechanisms of action of glucagon-like peptide-1 receptor agonists on blood pressure beyond body weight

These approaches aim to address one of the most challenging complications associated with joint replacement procedures

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