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On the high-dose sema-bima combination, patients lost exclusivley fat at 24 weeks and 90% fat mass at 48 weeks

The semaglutide itself is a compounded version, meaning its prepared by specialized pharmacies rather than manufactured under FDA-approved brand names like Ozempic or Wegovy

Briskey, D., Malfa, G

Like many clinicians, I initially thought about these drugs mostly in terms of weight loss and metabolic disease

Specific intervention scenarios of GLP-1 on cellular energy economics Treatment of diabetes: correcting the "imbalance of energy distribution" The core pathology of type 2 diabetes is insulin resistance and beta cell function failure, which leads to the imbalance of energy distribution: the intake of glucose by muscle and adipose tissue is reduced, the liver gluconeogenesis is increased, and the levels of glucose and FFA in the blood are increased, forming a vicious cycle of "hyperglycemia hyperlipidemia"