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Further, in vitro analysis observed that increasing doses of GLP-1 stimulate hypothalamic GnRH neurons by enhancing the mRNA levels of kisspeptin-1 (KISS-1), an HPG axis gatekeeper, together with increased GnRH mRNA expression, effects inhibited in the presence of a selective GLP-1R antagonist [141]

Fatigue that progressively worsens rather than improving over time may indicate an underlying issue requiring investigation

Here is the part worth pausing on, because it reverses the usual advice

Funding This study was supported by a grant of Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare (HF20C0002), The Basic Science Research Program through the National Research Foundation of Korea, funded by The Ministry of Education (2018R1A6A1A03025108), and the Research Fund of The Catholic University of Korea (2023)

In our previous discussion, we explored how the escalating consumption of ultra-processed foods (UPFs) triggers alarming neurological and metabolic disturbances