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The best area is between the hip and the knee, avoiding the inner thigh and areas close to the knee

The expression of intestinal endocrine Lcells is regulated by several key receptors activated by short chain fatty acids (SCFAs), specific endogenous cannabinoids and bile acids, and the activation of these receptors increases the secretion of key intestinal peptides, such as GLP-1, GLP-2 and polypeptide YY (PYY) (de Vos et al., 2022)

These drugs not only help lower blood sugar but also promote weight loss and may improve cardiovascular outcomes

9 kg), reduces depression scores and improves QoL dimensions such as mood and self-image, with changes correlating with the magnitude of weight loss (138)

Although no diagnostic guidelines exist specifically for GLP-1-related constipation, standard tests such as anorectal manometry and the balloon expulsion test can help identify patients who may benefit from this therapy