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Long-term Use and Potential Downsides Some individuals may find they need to remain on these medications indefinitely to maintain their weight and health benefits

Insulin levels and HOMA-IR : Useful for assessing insulin sensitivity

J Endocrinol , 217 (2), 185-196

The standard titration schedule for semaglutide involves starting at a low dosetypically 0.25 mg weekly for the first four weeksand gradually increasing every four weeks until reaching the maintenance dose