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The lower achievement rates may be attributed to the effects of concomitant antidiabetic drugs, as demonstrated in PIONEER 3 study, as well as the potential presence of insulin resistance resulting from chronic poor glycemic control

Discuss with your doctor which medication is best suited for you, taking into account your individual health needs and treatment goals

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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

The nine ROIs were defined according to the automated anatomical labeling atlas as previously described 49,57