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2021, NEJM) showed A1C reductions of 2.0 to 2.3 percentage points at the highest dose, the strongest A1C lowering of any approved diabetes drug

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Blood was collected from the saphenous vein, and blood glucose levels were measured using an ACCU-CHEK Guide Glucose Monitor and Testers (Roche) before each injection and at 10, 20, 30, 60, and 90 min after the glucose injection

Cardiovascular benefit for GLP-1RAs was shown in 2016 for liraglutide in the LEADER trial and semaglutide in the SUSTAIN 6 trial

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