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They are metabolised through different pathways and do not significantly affect each other's metabolism, though both can cause gastrointestinal side effects

Dual Agonists: The Twincretins The next major step in development involves drugs that combine a GLP-1 agonist with another hormone, a GIP (glucose-dependent insulinotropic polypeptide) agonist

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They are undertreated because trial populations have historically skewed male