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They joined prior risk factors such as hearing loss, hypertension, smoking, obesity, depression, physical inactivity, diabetes, excessive alcohol use, traumatic brain injury, air pollution, social isolation, and lower educational attainment

Weight loss was paralleled by a statistically significant decrease in BMI at M6 (3.4 kg/m 2 [2.5] vs.1.7 kg/m 2 [2.0]

Troglitazone activates TRPV1 and causes deacetylation of PPAR in 3T3-L1 cells

An integrative approach that considers not only the regulation of gene expression but also the functional consequences of these changes at the protein, metabolic and cellular pathway levels will be essential for advancing our understanding of these intricate disorders and developing effective interventions and treatments