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Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing data

Garrido-Santos for her valuable assistance in the preparation of Figure 1, which greatly enriched the quality of this review

Results To simulate the calorie restriction intervention in the CALERIE phase 2 study (7), the best fit model parameters were k = 82 kcal/d per kg and P(t) = 830 kcal/d resulting in a body weight change trajectory that plateaued after about 12 months with simulated body fat being slightly greater than the observations (Figure 1A)

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