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This means it makes it harder to lose weight due to the fewer calories your body burns at rest

The pilot data from liraglutide provides the rationale, and the mechanistic evidence supports the biological plausibility

Detailed Category Analysis# Receptor Targets# Retatrutide : Triple agonist: GIP, GLP-1, and glucagon receptors simultaneously Tirzepatide : Dual agonist: GIP and GLP-1 receptors Advantage : Retatrutide Weight Loss Efficacy# Retatrutide : Up to 28.7% body weight reduction at 68 weeks (Phase 3 TRIUMPH-4)

Cochrane Statistical Methods Group

Laboratory monitoring may include periodic assessment of kidney function, particularly in patients experiencing significant gastrointestinal symptoms