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14 In the SURMOUNT 1 trial, tirzepatide 15 mg/wk with general nutritional instructions produced a 20.9% reduction in body weight from baseline (versus 3.1% with general nutrition instructions alone), 15 whereas in the SURMOUNT 3 trial, tirzepatide 10 or 15 mg/wk started after 12 weeks of intensive lifestyle intervention produced a 25% reduction from baseline (versus 4.8% with intensive lifestyle intervention alone)

As such, its important to consider best practices for long-term use of semaglutide, no matter what your primary purpose is

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Obesity-linked PPAR S273 phosphorylation promotes insulin resistance through growth differentiation factor 3

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