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GLP-1RAs are generally well tolerated

When reviewing lipid panels in patients on semaglutide, providers should consider these potential improvements when assessing cardiovascular risk

This pathway has been beautifully illustrated by Krajnc et al

conducted target trial emulations comparing dual GLP-1/GIP agonists to GLP-1 monotherapy in patients with type 2 diabetes, finding that dual agonists were linked to numerically lower risks of MALOs, although confidence intervals overlapped, suggesting that extended observation period and larger patient cohorts may be needed to definitively establish comparative effectiveness [61]