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4 Discussion The clinical importance of DDI cannot be overemphasized

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In clinical trials investigating transdermal GLP-1 delivery systems, researchers have explored various wearing durations, including daily and weekly applications

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[6] Whilst the precise neuropsychiatric effects of GLP-1 receptor agonists remain under investigation, it is theoretically possible that modulation of these pathways could influence emotional states in susceptible individuals

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This has contributed to a significant increase in demand for and interest in GLP-1RAs around the world

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GLP-1 receptor signaling pathways

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