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Trends Endocrinol Metab 2013;24:8591 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Davies MJ, DAlessio DA, Fradkin J, et al
They can be injected once a week safely and effectively
Patient-submitted reports constituted 81.7% of NAEs, reflecting both expanded GLP-1 RA accessibility and growing public awareness of NAEs
In addition, a membrane-bound zinc metallopeptidase, neutral endopeptidase 24.11 (NEP 24.11), has also been shown to cleave GLP-1 at its C terminus both in vitro and in vivo (Plamboeck et al., 2005)
To understand the long-term safety and chronic effectiveness of these treatments, these studies will be essential
