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Because of this limited tool-kit of recombinant production, it is often paired with downstream chemical (or enzymatic) steps to add non-natural modifications While we did capture whether peptides are cyclical or linear, we did not look at more granular features (e.g., non-canonical amino acids, site-specific modifications)

However, some studies have recorded no significant changes or milder deficits in Rota Rod performance, reflecting differences in experimental protocols, such as training frequency

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